Jump to content

  • Log in with Facebook Log in with Twitter Log in with Windows Live Log In with Google      Sign In   
  • Create Account

Submit your paper to J Biol Methods today!
- - - - -

Enriched gene signatures

  • Please log in to reply
1 reply to this topic

#1 cath



  • Members
  • Pip
  • 1 posts

Posted 30 June 2011 - 04:37 PM


I have a gene expression signature (ie list of genes up and down) which I would like to check against a gene expression profile to see if the signature is enriched in a particular subset of samples in the profile. I was thinking I'd use GenePattern to extract the signature genes from my expression profile or perhaps from a hierarchical cluster of my expression profile to see if they are enriched in a particular subset of samples. Does this sound like a reasonable approach?

Many thanks in advance for any advice,


#2 pcrman



  • Global Moderators
  • PipPipPipPipPipPipPipPipPipPip
  • 1,165 posts

Posted 22 August 2011 - 06:11 PM

I think what you need is Gene Ontology analysis. To do so, you just need to compile a list of genes (IDs or symbols) and then choose an online or locally installed GO analysis program to run the assay. The program will return a list of categories in which your genes are enriched or depleted. To find out a list of such program, http://www.geneontol...icroarray.shtml

Home - About - Terms of Service - Privacy - Contact Us

©1999-2013 Protocol Online, All rights reserved.