How to deal with cancer drug resistance
Posted 11 June 2011 - 11:42 AM
Combination or coktail of multiple drugs can have serious side-effects. What other general ideas can provide better solutions on drug design and cancer treatment.
Posted 12 June 2011 - 10:17 PM
Posted 17 June 2011 - 03:39 PM
Hi Protodler, sorry to reply late. Your answer went to a different question. The question I asked is how to deal with cancer cell resistance due to cell rescue by alternative pathways. MDR-based drug resistance is mainly caused by cell membrane molecule-delivery mechanism if I'm correct.
Right now, many drugs are developed to block one or few signal transduction pathways. Cancer cells can survive by complementary pathways. How we find a way to prevent cancer cell self-rescue? That's my question.
Posted 19 August 2011 - 08:54 PM
If you want to learn more about drug resistance in HIV-1 protease and HCV NS3/4A protease, please read the publications from my lab - Celia Schiffer's lab in UMass Medical School. Maybe there is something applicable to cancer as well, because there are parallel mechanisms in drug resistance that we saw in Influenza, antibiotic resistance and fungal resistance.
Other than that, there are few groups who are working on coping with the resistance issue by not directly perturbing the active site of a protein but trying to find molecules that will allosterically inhibit the target molecule. You can also search their strategies on to how to cope with drug resistance.