Jump to content

  • Log in with Facebook Log in with Twitter Log in with Windows Live Log In with Google      Sign In   
  • Create Account

Submit your paper to J Biol Methods today!
Photo
- - - - -

isolation and sequencing of peptide on MHC class I


  • Please log in to reply
No replies to this topic

#1 mik-i

mik-i

    member

  • Active Members
  • Pip
  • 9 posts
0
Neutral

Posted 03 June 2011 - 02:41 AM

Hello!


I have a general question. In auto-immune muscle diseases, self-peptides are loaded onto MHC class I or class II molecules and presented to immune cells, eliciting an auto-immune reaction. I was wondering why it seems to be impossible to isolate and sequence the loaded peptide, and why it can't be identified by performing a peptide blast (=a bio-informatics approach). Why can't it be done when it is already known that the peptide is bound into the cleft of MHC molecules?

mik-i




Home - About - Terms of Service - Privacy - Contact Us

©1999-2013 Protocol Online, All rights reserved.