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Microarray data bimodal distribution of intenstiy values


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#1 rachgibson

rachgibson

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Posted 06 May 2011 - 04:12 AM

Hi there

I was wondering if anyone could please give me some advice, I have two independent sets of microarray data which are Agilent one colour for gene expression. My plan was to compare Wildtype to mutant expression profiles. I am having major problems as all samples, mutant and the wildtype, show a bimodal distribution of intensity. I was wondering if anyone else has experienced this and has any advice? I am new to microarrays and completely lost? The data is not normally distributed so am unable to use conventional modelling/ bioinformatic resources like babelomics as all assume a normal distribution.

Any advice would be greatly appreciated

Thanks
Rachel




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