4 replies to this topic

[jerseysurfer66]

Wanted discussions on how enzymes reach 10^16+ rate increases and what can be done to design enzymes with similar rate increases.

I'll start the discussion by saying that I don't believe transition state stabilization results in the bulk of the rate increase in enzyme catalysis.

[Kaioshin]

jerseysurfer66, on 24 April 2011 - 10:36 AM, said:

Wanted discussions on how enzymes reach 10^16+ rate increases and what can be done to design enzymes with similar rate increases.

I'll start the discussion by saying that I don't believe transition state stabilization results in the bulk of the rate increase in enzyme catalysis.

How can we design our own enzymes?
For starters, we need to gather ~1 trillion more years in man hours worth of research...

[jerseysurfer66]

Agree on that we need much more research but highly doubtful a trillion years is necessary.  This is a next 10 year development.

[Kaioshin]

jerseysurfer66, on 24 April 2011 - 07:23 PM, said:

Agree on that we need much more research but highly doubtful a trillion years is necessary.  This is a next 10 year development.

You should probably look up the definition of "man hours"

[jerseysurfer66]

U should try and understand the number "a trillion" .