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Threshold for differential expression in 2D gels experiments


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#1 barnacleman

barnacleman

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Posted 28 March 2011 - 07:40 AM

Hi,

I am curious why the threshold for 'differential change' in 2D gels experiments always select 1.5 or 2 fold change in addition to statistical difference. Specifically,

(1)Why were changes limited to either 1.5 fold/2-fold or greater?


(2)Could there not be a highly significant change of a smaller magnitude? How would you justify spots in this situation?

Thanks.




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