I'm proposing to study polymorphisms in breast cancer antigens. Do any of you think I can do this study by blood samples.... where I can check out the polymorphisms in that particular antigen coding gene eg- BRCA gene.... can this be used for diagnostic purpose?
Or do you people think I need to be tissue specific for the identification of polymorphism?
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BioMiha
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Posted 21 March 2011 - 08:53 AM
Polymorphisms are DNA encoded, so any cell source will do.
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flysui
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Posted 19 June 2011 - 11:39 PM
InduS, on 21 March 2011 - 08:43 AM, said:
I'm proposing to study polymorphisms in breast cancer antigens. Do any of you think I can do this study by blood samples.... where I can check out the polymorphisms in that particular antigen coding gene eg- BRCA gene.... can this be used for diagnostic purpose?
Or do you people think I need to be tissue specific for the identification of polymorphism?
Or do you people think I need to be tissue specific for the identification of polymorphism?
The differences(such as gene expression, DNA methylation, etc.) found in a non-target tissue, can be used as biomarkers in a disease. I think you can discover SNPs in peripheral blood as biomarkers of breast cancer. for instance: 2011, Marsit CJ _DNA methylation array analysis identifies profiles of blood-derived DNA methylation associated with bladder cancer.
