Jump to content

  • Log in with Facebook Log in with Twitter Log in with Windows Live Log In with Google      Sign In   
  • Create Account

Submit your paper to J Biol Methods today!
Photo
- - - - -

Differences between cells in different species


  • Please log in to reply
5 replies to this topic

#1 capriccio

capriccio

    member

  • Members
  • Pip
  • 2 posts
0
Neutral

Posted 24 February 2011 - 02:48 PM

Hi guys
I'm no biologist, so I'm sorry if these questions sound stupid.
But I was wondering what are the differences between cells from different species ? For example, I have fibroblasts or osteoblasts from human and from mice. How are they different from each other ?

The same question goes to proteins. If I have fibronectin from human, how is it different from bovine fibronectin ?

#2 bob1

bob1

    Thelymitra pulchella

  • Global Moderators
  • PipPipPipPipPipPipPipPipPipPip
  • 5,833 posts
415
Excellent

Posted 24 February 2011 - 03:09 PM

Sequence often varies to some extent both at DNA and protein levels. However, they tend to work in the same manner and interact with the same proteins etc.

#3 Sora

Sora

    member

  • Active Members
  • Pip
  • 6 posts
0
Neutral

Posted 24 February 2011 - 05:28 PM

different species are meant to survive in different conditions and their cells are supposed to respond slightly differently. Sometimes a drug seems to work perfectly in mice but shows a lot of side-effects in humans. I once compared endothelial cells from mice and rat (pretty close species) and although they were same in most respects, they did respond differently to certain stimuli! But, response in cells from one species can be indicative of the kind of response you would get in cells from another.

#4 capriccio

capriccio

    member

  • Members
  • Pip
  • 2 posts
0
Neutral

Posted 24 February 2011 - 10:26 PM

Thank you for the input. So I guess there are chances that human fibronectin and rabbit anti-fibronectin won't react. Right ?

#5 Rnotk

Rnotk

    Enthusiast

  • Active Members
  • PipPipPipPipPip
  • 89 posts
3
Neutral

Posted 25 February 2011 - 12:00 PM

what do you mean "react"??

#6 bob1

bob1

    Thelymitra pulchella

  • Global Moderators
  • PipPipPipPipPipPipPipPipPipPip
  • 5,833 posts
415
Excellent

Posted 25 February 2011 - 03:48 PM

Is it an antibody raised in rabbit against human fibronectin or is it an antibody against rabbit fibronectin raised in some other species? If you have the epitope of the antibody you should be able to check on the NCBI or other database as to whether the epitope is present in humans or other species that have been sequenced.




Home - About - Terms of Service - Privacy - Contact Us

©1999-2013 Protocol Online, All rights reserved.