I am studying a protein which is probably a transcription factor (it encodes a transcription factor domain although this domain is not involved in DNA-binding). Bioinformatics predictions show that apparently the protein does not have DNA-binding motifs, although I have functional data highly suggestive of the protein being involved in gene expression regulation.
Is it possible that it is a non-binding transcription factor? Are these proteins common? Do they have particular features? Could it be interacting with a DNA-binding molecule allowing the regulation of gene expression? Does anyone know how I can predict this and look for the putative mediator(s)?
A big thanks for anyone who can help!
Edited by cardosopedro, 14 January 2011 - 08:09 AM.