chimeric transcription factor
Posted 20 December 2010 - 12:32 PM
Does anyone knows what the term "chimeric" means in connection with a transcription factor?
My assumption is that a transcription factor is called "chimeric" if it can be activated by a
molecule which derives from another species.
I'll be happy if someone is can give me the exact definition.
Posted 28 December 2010 - 12:06 PM
Hope it convinced you.
Posted 01 January 2011 - 09:42 AM
But that summons up another question: What is a "dys-regulation"?
I understood your explanations this way: I have a transcription that causes gene expression
of a specific gene. And if this transcription factor is transformed into it's chimeric form it
will activate the gene expression of an other gene?
Posted 27 January 2011 - 03:04 PM
I would think that a chimeric transcription factor would be a factor with fragments/domains of different origins, not necessarily disregulated, for example:
Transcription factor A with the DNA binding domain of transcription factor B, or, mouse transcription factor A with human transcription factor A Nuclear Localization Signal.
It could potentially retain function but the protein would be chimeric...
Posted 30 January 2011 - 09:38 AM
synthesized of different building block that come from different species.