Posted 20 December 2010 - 07:33 AM
I would like to label the statins simvastatin and rosuvastatin to any fluorescent dye ( I can almost detect every dye). Please find attached both statins complexed to the HMG-CoA-Reductase (target of the statins).
For simvastatin, there is a COOH-group that may be a good link. However, a spacer may be necessary. Further information can be find here http://www.pdb.org/p...tructureId=1HW9
For rosuvastatin I guess the CH3-group could work. Further informations http://www.pdb.org/p...tructureId=1HWL
In both cases I do not know which dye to choose and how to link it to the statins. Unfortunately, I am not a chemist but studied biotechnology so I have some ideas but not expert ideas.
So could anybody help?
Thanks a lot!
PS: You can also answer in German.
Posted 30 December 2010 - 03:34 AM
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Posted 30 December 2010 - 06:45 AM
genius does what it must
i do what i get paid to do