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Can every gene be methylated?


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#1 jdunn

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Posted 17 December 2010 - 11:00 AM

Hi all,
I am new to the field of epigenetics and I am digging through a list of genes relevant to my work that I want to try a methylation study on. To reduce the size of my list I was wondering if there are any genes I can rule out as not possible (or unlikely) to be methylated. For example, does every gene have a CpG island, and if a gene doesn't, may I use this as an indicator that it won't become methylated?
I appreciate any advice you can lend!
Thanks!

#2 methylnick

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Posted 17 December 2010 - 04:22 PM

hard to say as methylation is tissue specific.

look at UCSC Genome browser, there is methyl-seq and Infinium 27K array data on the hg18 freeze that can point you somewhat to what is methylated and not on a genome scale.




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