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influence of posttranslational modifications on proteolysis of peptides


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#1 markusda

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Posted 05 November 2010 - 03:54 AM

hey,

for those who are familiar with proteases and proteolysis: I'm wondering, if posttranslational modifications have a significant influence on the spcificity of proteases and proteolysis. Does for example phosphorylation of a certain serine or threonine of a small peptide prevent efficient proteolysis of the peptide ? Has the phosphate to be remnoved by phosphatases before ?

Any literature suggestions ?

Markus

#2 bob1

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Posted 05 November 2010 - 08:38 PM

The only one I can think of off the top of my head is that ubiquitylation (ubiquitination) is the signal for degradation by the proteasome.




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