for those who are familiar with proteases and proteolysis: I'm wondering, if posttranslational modifications have a significant influence on the spcificity of proteases and proteolysis. Does for example phosphorylation of a certain serine or threonine of a small peptide prevent efficient proteolysis of the peptide ? Has the phosphate to be remnoved by phosphatases before ?
Any literature suggestions ?
influence of posttranslational modifications on proteolysis of peptides
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