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looking for kinase inhibitor to study phosphatase


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4 replies to this topic

#1 UNO

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Posted 15 September 2010 - 02:19 AM

Hey all,

Would like to find out is there any available kinase inhibitor(s) to inhibit phosphorylation on transmembrane receptor? Are they kinase dependent or is there a chemical which can do just a specific one?

Warmest regards,
UNO

#2 rkay447

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Posted 15 September 2010 - 09:25 AM

Hey all,

Would like to find out is there any available kinase inhibitor(s) to inhibit phosphorylation on transmembrane receptor? Are they kinase dependent or is there a chemical which can do just a specific one?

Warmest regards,
UNO

There are many different kinase inhibitors available. Some inhibit specific kinases, some inhibit classes of kinases and some inhibit a wide variety. Do you have a specific kinase in mind that you want to inhibit? For example, I use roscovitine to inhibit the cyclin-dependent kinases.

#3 Inmost sun

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Posted 24 September 2010 - 06:14 AM

Hey all,

Would like to find out is there any available kinase inhibitor(s) to inhibit phosphorylation on transmembrane receptor? Are they kinase dependent or is there a chemical which can do just a specific one?

Warmest regards,
UNO


receptor tyrosine kinases are both cis- and transphosphorylated whereas G-protein coupled receptors are only cisphosphorylted; you have to choose the right inhibitor to block the phosphorylation of a specific site...

#4 castleinthesky

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Posted 22 February 2012 - 02:27 AM

Kinase inhibitors can specifically block the activity of one or more protein kinases.

Edited by castleinthesky, 22 February 2012 - 02:30 AM.


#5 PhDinAcronyms

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Posted 09 April 2012 - 05:24 PM

Sigma aldrich has several application notes on kinase inhibitors which list many inhibitors and their targets




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