4 replies to this topic

[UNO]

Hey all,

Would like to find out is there any available kinase inhibitor(s) to inhibit phosphorylation on transmembrane receptor?  Are they kinase dependent or is there a chemical which can do just a specific one?  

Warmest regards,
UNO

[rkay447]

UNO, on 15 September 2010 - 02:19 AM, said:

Hey all,

Would like to find out is there any available kinase inhibitor(s) to inhibit phosphorylation on transmembrane receptor?  Are they kinase dependent or is there a chemical which can do just a specific one?  

Warmest regards,
UNO

There are many different kinase inhibitors available.  Some inhibit specific kinases, some inhibit classes of kinases and some inhibit a wide variety.  Do you have a specific kinase in mind that you want to inhibit?  For example, I use roscovitine to inhibit the cyclin-dependent kinases.

[Inmost sun]

UNO, on 15 September 2010 - 02:19 AM, said:

Hey all,

Would like to find out is there any available kinase inhibitor(s) to inhibit phosphorylation on transmembrane receptor?  Are they kinase dependent or is there a chemical which can do just a specific one?  

Warmest regards,
UNO

receptor tyrosine kinases are both cis- and transphosphorylated whereas G-protein coupled receptors are only cisphosphorylted; you have to choose the right inhibitor to block the phosphorylation of a specific site...

[castleinthesky]

Kinase inhibitors can specifically block the activity of one or more protein kinases.

Edited by castleinthesky, 22 February 2012 - 02:30 AM.

[PhDinAcronyms]

Sigma aldrich has several application notes on kinase inhibitors which list many inhibitors and their targets