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[Scotty]

Hi everyone,

I'm new in the field of epigenetics, and I have been reading recent papers on DNA methylation. I realized that the focus in the past 10 years has really been on the methylated cytosine, and I have several questions and would appreciate your thoughts:

1. Has anyone ruled out the possibility of other methylated bases e.g. methylated guanine, adenine or thymine as possible epigenetic marker?
2. When was methylated cytosine first found? Was it discovered through a systematic study that look at all DNA bases before identifying cytosine as the only methylated base?
3. The discovery of 5-OHMe Cytosine is interesting, do you all think that there are more to come? Why yes or why no?

I've been trying to find answers/hints to these questions without much success, I would really appreciate your insights and suggestions.

Thank you a million!!

Scotty