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Potency, Free Base and Lot Purity

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#1 cell the truth

cell the truth


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Posted 19 August 2010 - 03:41 AM

Hi Everybody,

we have a problem concerning solutions. on our chemicals are several informations, such as molecular weights and water content and lot purity. there are also informations like potency. whats that? we like to know now what the mass/amount of free base in our dilutions is. how should we calculate this? is there a kind of "official calculation"?

Tobramycin sulfate salt as an example:

Molecular Weight: 467.51 (free base basis)
Weight Ratio (base/salt): 0.656
Water content: 2%
Sulfate content: 2.5mol/mol
Purity: 98%
Potency: 712 ug/mg

To repeat: We don't understand whats included in the value of potency. Is it the amount of pure free base per milligramm? Or is it the amount of salt per milligram? Or something else?

Thanks in advance,

Edited by cell the truth, 19 August 2010 - 04:53 AM.

If you are not part of the solution you are part of the precipitate.

#2 Gerard



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Posted 22 August 2010 - 01:26 AM

Look into this PDF
Ockham's razor
Pluralitas non est ponenda sine necessitate
-- "You must assume no plural without necessity".

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