Posted 15 July 2010 - 03:16 AM
Which means that the arrival of a wonder to reach an aim is an integral part of the work principle?
I guess it is more to find than imaginated...
Posted 15 July 2010 - 03:20 AM
Posted 15 July 2010 - 05:09 AM
Posted 15 July 2010 - 05:17 AM
- hobglobin, personal comment about my beauteous photo......
Posted 15 July 2010 - 10:05 AM
One must presume that long and short arguments contribute to the same end. - Epicurus
...except casandra's that belong to the funniest, most interesting and imaginative (or over-imaginative?) ones, I suppose.
Posted 15 July 2010 - 05:10 PM
All praise the Goddess of Molecular Biology for great is her power.
Posted 16 July 2010 - 05:25 AM
I am sorry to be unclear, I think the better phrase than wonder is "miracle"
f.i., you must believe in miracles if you have to look for a needle in a haystack, and the PI suggests that work will be done within 1 or two months "with some luck"
Setting ambitious aims in an irrealistic time schedule AND to be sure to reach the aims within this time table indicates a belief in miracles, doesn´t it?
I am interested if other members have such experiences with seekers after miracles who better had become gurus than scientists...
and how you deal with it
Posted 16 July 2010 - 05:56 AM
Even if you are looking for a needle in hay stack, U need to follow some scientifically rational and reproducible protocol based on facts to call it science rather than randmly search.
Posted 17 July 2010 - 08:55 PM
Sounds like my former supervisor, although he categorically did not believe in luck. He did believe in massive parallelism.
In life we can't repeat the same event in a dozen different ways, and only stop to pick the reality where things worked out to produce a desired outcome.
But for some methods in science, parallelism is possible and thus "miracles" can happen.
In many ways there is an element of luck in the construction of a plasmid or BAC. Which colony on a plate amongst a hundred will contain a properly ligated plasmid, nobody knows. You would have to test them.
Now if the probability of a colony containing a structurally correct plasmid was 1/100 and you only tested 30 colonies, you would need a bit of "luck" to find this 1/100 colony. And imagine if you had to build 6 such plasmids in the space of a month or two, all requiring instances of such "luck" for their construction.. it would then become a miracle to complete the project on schedule.
But what would happen if you could easily and quickly test 100 or better yet 300 colonies (for instance with the help of a multichannel pipette/PCR or a robot). Now, what once a lucky event becomes a certainty. And a miracle is reduced to an everyday chore.
This probably isn't quite what you had in mind. But I guess I am try to say is with some ingenuity, perhaps a change in methods, it is sometimes possible to incorporate parallelism into an experiment design. This allows the isolation of a desired outcome even if the probability of a successful event is rare,
Posted 18 July 2010 - 03:49 AM
Posted 19 July 2010 - 12:22 AM
so most it is hope what you describe as looking for miracles??? And timeplans never work out, this would be a miracle itself.