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Can miRNAs regulate miRNA expression


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#1 mirstarter

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Posted 21 June 2010 - 06:07 AM

Does anyone know the mechanisms of reciprocal regulation of miRNAS?

#2 pcrman

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Posted 21 June 2010 - 11:06 AM

If a miRNA regulates another miRNA, I guess the regulation is likely at the transcription level and such regulation is possible.

#3 Jon Moulton

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Posted 22 June 2010 - 06:31 AM

Here's a paper describing a feedback loop that results in an miRNA regulating its own expression. That's as close as I can come at the moment.

http://www.ncbi.nlm....pubmed/20236986
Jon D. Moulton
Gene Tools, LLC
www.gene-tools.com

#4 andrea massimo

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Posted 23 June 2010 - 07:17 AM

In plants are known at least a couple of feedback mechanisms: miR162- mediated dicer-like 1 transcript cleavage and miR168-mediated AGO1 transcript cleavage. While both act on the general pathways of miRNA biogenesis and action, there are no reported interactions between specific miRNAs, as far as I know.




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