3 replies to this topic

[mirstarter]

Does anyone know the mechanisms of reciprocal regulation of miRNAS?

[pcrman]

If a miRNA regulates another miRNA, I guess the regulation is likely at the transcription level and such regulation is possible.

[Jon Moulton]

Here's a paper describing a feedback loop that results in an miRNA regulating its own expression.  That's as close as I can come at the moment.

http://www.ncbi.nlm....pubmed/20236986

[andrea massimo]

In plants are known at least a couple of feedback mechanisms: miR162- mediated dicer-like 1 transcript cleavage and miR168-mediated AGO1 transcript cleavage. While both act on the general pathways of miRNA biogenesis and action, there are no reported interactions between specific miRNAs, as far as I know.