Jump to content

  • Log in with Facebook Log in with Twitter Log in with Windows Live Log In with Google      Sign In   
  • Create Account

Submit your paper to J Biol Methods today!
Photo
- - - - -

polarized cells


  • Please log in to reply
4 replies to this topic

#1 Sayeh

Sayeh

    member

  • Active Members
  • Pip
  • 19 posts
0
Neutral

Posted 17 June 2010 - 01:37 PM

Hi everyone,
I am wondering if some one can explain to me what “polarized cell” means? Does it refer to cell morphology?
Thanks!

#2 jakatta70

jakatta70

    Enthusiast

  • Active Members
  • PipPipPipPipPip
  • 40 posts
0
Neutral

Posted 18 June 2010 - 01:26 AM

Hi,

In terms of macrophages if a macrophage has been matured with, say, LPS+IFNg, then it becomes POLARIZED to a classically activated state ie it will respond by producing TH1 cytokines in response to appropriate stimulus. If the macrophage is matured with TH2 cytokines, such as IL-4 + IL-13, it becomes POLARIZED to an alternatively activated state ie responds to stimulus with TH2 cytokines. Also unique markers for each polarized state will decrease or increase depending on what sort of macrophage you have polarized the initial macrophage to.

I don't think polarization has much to do with morphology although. I wouldn't think so. If a monocyte matures to a macrophage I would think that would be CONVERSION. I think POLARIZATION is more complicated and intricate.

I hope this helps you a bit.

#3 jakatta70

jakatta70

    Enthusiast

  • Active Members
  • PipPipPipPipPip
  • 40 posts
0
Neutral

Posted 18 June 2010 - 01:30 AM

Hi again,

Ignore my last post. I'm incorrect!

Here is a good review on the subject:

http://www.nature.co...rity/index.html

#4 Sayeh

Sayeh

    member

  • Active Members
  • Pip
  • 19 posts
0
Neutral

Posted 21 June 2010 - 10:20 AM

Hi again,

Ignore my last post. I'm incorrect!

Here is a good review on the subject:

http://www.nature.co...rity/index.html



Thanks a lot!

#5 Inmost sun

Inmost sun

    Veteran

  • Active Members
  • PipPipPipPipPipPipPipPipPipPip
  • 315 posts
60
Excellent

Posted 21 June 2010 - 12:25 PM

Hi everyone,
I am wondering if some one can explain to me what “polarized cell” means? Does it refer to cell morphology?
Thanks!


full differentiated epithelial cells are polarized in apical, lateral and basal domains




Home - About - Terms of Service - Privacy - Contact Us

©1999-2013 Protocol Online, All rights reserved.