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why are some cell lines more popular than others??


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4 replies to this topic

#1 moljul

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Posted 14 May 2010 - 05:44 AM

currently i am busy doing searching the "right" cell lines for my experiements!
i am not that familiar with colorectal, mammary gland, prostate and pancreas carcinoma cells!

i am in general interested why some cell lines got so "popular" - why are they the bestsellers and published so often!!

colorectal: CaCo-2, HCT116...
prostate: DU145, LNCap, PC3...
mammary gland: MCF-7, MDA-MB-231...
pancreas: Panc-1, MIA PaCa-2...

ths in advance

#2 bob1

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Posted 16 May 2010 - 04:31 PM

Easy to grow is a big player, also some are better characterised than others, some have particular characteristics that are representative of a particular cell type or express genes in a more "normal" fashion.

#3 tea-test

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Posted 17 May 2010 - 03:17 AM

in breast cancer cells , for instance, you can differentiate between hormone dependent (-> MCF-7) and hormone-independent (->MDA-MB-231) cell lines.

or if you want to have a model for an epithelial tumor you should not choose a cell line that was established from a stromal tumor. that's what common sense is telling me :(
tea-test: The artist formerly known as Ned Land

#4 arera

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Posted 26 May 2010 - 06:49 PM

in breast cancer cells , for instance, you can differentiate between hormone dependent (-> MCF-7) and hormone-independent (->MDA-MB-231) cell lines


Good comment tea test!!! :P

#5 Inmost sun

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Posted 27 May 2010 - 01:08 PM

currently i am busy doing searching the "right" cell lines for my experiements!
i am not that familiar with colorectal, mammary gland, prostate and pancreas carcinoma cells!

i am in general interested why some cell lines got so "popular" - why are they the bestsellers and published so often!!

colorectal: CaCo-2, HCT116...
prostate: DU145, LNCap, PC3...
mammary gland: MCF-7, MDA-MB-231...
pancreas: Panc-1, MIA PaCa-2...

ths in advance


I think it is an evolutionary process; one or some start with a cell line and establish handling, biological parameters and scientic questions ("hormone dependency" was argued); so it is more easy to refer to previous works than establishing a novel cell line




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