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how long can disulfide bonds of human immunoglobulin be broken in HCl (PH=2.8)?


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#1 trigon

trigon

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Posted 04 May 2010 - 02:39 PM

The Ag/Ab interactions can be dissociated in acidic conditions, say PH=2.8. How are the disulphide bonds of Ab involved in such conditions? Are they also broken like the non-covalent bonds? At what PH value the non-covalent bonds are broken while the disulphide bonds of Ab can be preserved?




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