A sufficient level of extracellular calcium is required for cells to pass into, and out of, the G1 phase of the cell cycle. If biological specimens are treated with a chelator of calcium, such as a citrate solution, in order to inhibit coagulation, then there can be insufficient calcium.
In my searching I have identified that some G1 arrest conditions are reversible, and some are not. Does anybody know if G1 arrest caused by a lack of calcium is reversible or not? Even if it is reversible, how likely is it that the cells will be damaged by calcium flux if suddenly re-exposed to physiologic levels of calcium, the so-called "calcium paradox".
The literature has a lot of hints, but I have not found anything directly on point. Or is this one of those questions, the answer to which is "it all depends"!
When is G1 arrest reversible?
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