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evolutionarily conserved RNA secondary structures in multiple sequence alignment


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#1 blaszcz

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Posted 23 January 2010 - 02:32 AM

Hi
I have an alignment of RNA sequences of the same region in mRNA from multiple organisms and I want to know is there any structure conservation. I have a experimental data of this region in human RNA so it will be grate to look on this region in other organisms

Can You help me to choose right way to do this?

best

blaszcz

#2 Felipillo

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Posted 24 January 2010 - 09:54 PM

May be this link could be useful for you
 http://www.openwetware.org/wiki/Wikiomics:RNA_secondary_structure_prediction#Comparative_structure_prediction

Edited by Felipillo, 24 January 2010 - 09:54 PM.

Chance favors the prepared mind
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#3 toejam

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Posted 26 January 2010 - 09:02 AM

the right way to do it would be finding papers where people have published similar analyses to what you are aiming for.
ie considering things such as species codon usage, type of alignment to perform, and so on.

cheers.
"When there's no more room in hell the dead will walk the Earth"




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