What does anti-cytokine do? how is it effective invivo? what is the molecular basis of this? what is actually happening? How is this concept used in labs?
no clue. any info will be helpful.
Thanks,
M
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CellSpecific.com
Posted 18 November 2009 - 07:45 AM
In general, the idea is to inhibit/block cytokine function. One approach uses antibodies specific to cytokines that when administered in vivo or in vitro results in cytokine binding and neutralization (cytokine cannot bind its receptor on target cell). This approach has shown promising therapeutic benefits as you'll see in your literature search.
One example of anti-cytokine application in the lab is to use antibodies to neutralize cytokine effects to favor or skew cell differentiation. Here is one thread (http://www.protocol-...ic=9881&hl=th17) in which such application is discussed. There are many other applications, but I'll leave those comments for others to give.
One example of anti-cytokine application in the lab is to use antibodies to neutralize cytokine effects to favor or skew cell differentiation. Here is one thread (http://www.protocol-...ic=9881&hl=th17) in which such application is discussed. There are many other applications, but I'll leave those comments for others to give.
Edited by CellSpecific.com, 18 November 2009 - 07:46 AM.
