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Fas death receptor inhibitor

Started by pmaj, Oct 19 2009 10:39 AM

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#1 pmaj

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Posted 19 October 2009 - 10:39 AM

Greetings,

Does anyone know a small molecule inhibitor for Fas (a cell death receptor) and where can I order it from? I need it to inhibit Fas signaling for cells in culture.

Thanks

Pmaj:-)

There is a fine line between persistence and obstinacy. I have come to realize the key is to choose a problem that is worth persistent effort.
~Judah Folkman

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#2 blotted

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Posted 21 December 2009 - 07:23 AM

pmaj, on Oct 19 2009, 07:39 PM, said:

Greetings,

Does anyone know a small molecule inhibitor for Fas (a cell death receptor) and where can I order it from? I need it to inhibit Fas signaling for cells in culture.

Thanks

Pmaj:-)

You could use antibodies against Fas receptor or Fas ligand:

the neutralizing antibody against the FAS-receptor (5 µg in phosphate-buffered saline; clone ZB4; Upstate Biotechnology, Lake Placid, NY) or FAS-ligand (5 µg in phosphate-buffered saline; clone NOK-1; BD Biosciences)

and also you could use inhibitor of caspase-8.

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#3 bob1

Hmmm, I think it's working

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Posted 21 December 2009 - 03:54 PM

You could try knocking down the Fas... though it would add quite a bit of complexity to the experiments.

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