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miR family

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#1 root



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Posted 22 September 2009 - 01:01 AM

Please help with the following questions:
What is exactly the definition of miR family? Does it mean: a group of different miRNA genes from which mature miRs with the same sequence (up to 2 mismatches) are produced?
What about overlapping miRs from the same miRNA gene?
If I have a long list of miRs, how can I devide them into family groups?

Many thanks,

#2 miRNA man

miRNA man


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Posted 23 September 2009 - 05:25 AM

If 2+ miRNAs have the same seed sequence (nt 2-8) then they are part of the same family, i.e. miR-15 and miR-16. Additionally, if there are 2 miRNAs very similar with only 1 or 2 nt differences, they are named with a letter after the number, i.e. miR-15a and miR-15b.

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