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self-renewal Vs proliferation


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3 replies to this topic

#1 BioPe

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Posted 07 September 2009 - 07:11 AM

Hello all!

I havenīt posted for some time. I guess that is why my nick was cancelled. Anyways I created a new one. Lol

My question is regarding stem cells:

What is the difference between 'self-renewal' and 'proliferation'?
Is it possible to distinguish experimentaly self-renewal and proliferation? The assays that are performed in the literature (spheres cultures, serial passages of cells in animals) prove that cells have proliferation ability or self-renewal?


Thanks guys,
BioPe.
:blink:

#2 swanny

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Posted 07 September 2009 - 06:41 PM

Hello all!

I havenīt posted for some time. I guess that is why my nick was cancelled. Anyways I created a new one. Lol

My question is regarding stem cells:

What is the difference between 'self-renewal' and 'proliferation'?
Is it possible to distinguish experimentaly self-renewal and proliferation? The assays that are performed in the literature (spheres cultures, serial passages of cells in animals) prove that cells have proliferation ability or self-renewal?


Thanks guys,
BioPe.
;)

Very briefly, self-renewal leaves the number of cells roughly the same, where proliferation increases the number of cells.

Welcome back to the forum. What was your original nickname?
Heart disease kills more women than breast cancer, but heart attack symptoms differ from men's symptoms. Get to know your heart... it could save your life.

#3 BioPe

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Posted 08 September 2009 - 11:18 AM

Thanks Swanny!

I suppose assimetric self-renewal leves the number of cells unchanged but what about simetric self-renewal, in which 1 stem cell gives rise to two stem cells? Shouldn't this expand the population of cells? I am confused... :)

My old nickname was BioPe, just like the one I created. :)
I think I haven't posted anything since last Christmas. I donīt know why I could not login. LOL

#4 BioLab

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Posted 18 May 2011 - 10:45 AM

Hello all,

Sorry to bring up an old topic, but I still can't get the difference between self-renewal and proliferation of HSC.

Many thanks.




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