"Here we describe a morpholino-based gene knockdown microinjection protocol to interrogate gene function at the maternal-embryonic transition."

Yao M, Leong D, Hanh-Windgassen A, Foygel K, Jun S, Behr B. Morpholino-mediated gene knockdown in the early mouse embryo. Nature Protocols 2009 DOI: 10.1038/nprot.2009.110