Hi everyone!

I'm studying DNA methylation changes in stem cells development. I see stem cell development even in the absence of DNA methylation of some important genes related to differentation. Our hypothesis is that, in our context, stem cell development can happen in the absence of DNA methylation but we'd like to carry out an experiment to demonstrate it. We thought interfering DNMTs and check if in the absence of DNMTs stem cell development can occur. Do you know some experiments I could perform??
Thank you so much!!