DNA sequencing (View forum version)


Posted 22 August 2013 - 05:52 AM

hello all,


this is a random question but what did scientist do before DNA sequencing was discovered? were there any other alternatives?


Thanks a bunch :)


Posted 22 August 2013 - 01:10 PM

Restriction digest mapping springs to mind.


Posted 22 August 2013 - 02:11 PM

I'd recommend that you read some of the experiments from that time. Heroic efforts were needed to determine what was happening, and it is (to me) inspiring to read about them. Khorana's determination of the genetic code is perhaps one such inspiring set of experiments.