BioProduct : Chemicals & Compounds : YM155
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Product Name YM155
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Product Description YM155, a novel small molecule survivin inhibitor, suppressed expression of survivin and induced apoptosis in PC-3 and PPC-1 human HRPC cell lines at 10 nmol/L. In a s.c.xenogr afted PC-3 tumor model in mice, 3-day continuous infusions of YM155 at 3 to 10 mg/kg induced massive tumor regression accompanied by suppression of intratumoral survivin. Pharmacokinetic analyses indicated that YM155 is highly distributed to tumors and at concentrations f20-fold higher than those in plasma.
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Price $155
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Vendor Information Selleck
2626 South Loop West, Suite 225, Houston, TX 77054 USA