BioProduct : Chemicals & Compounds : MLN8237
Previous  Next
Visit the product
Product Name MLN8237
Product PageVisit the Product
Product Description MLN8237 is a second-generation, orally bioavailable, highly selective small molecule inhibitor of the Aurora A kinase (serine/threonine protein kinase) with potential antineoplastic activity. [1] MLN8237 binds to and inhibits Aurora A kinase, which may result in disruption of the assembly of the mitotic spindle apparatus, disruption of chromosome segregation, and inhibition of cell proliferation. [1] After treatment in eight multiple myeloma cell lines with MLN8237 (0.0001 M C 4 M) for 48 h, the affect of Aurora A kinase inhibition and a marked effect on both viability and proliferation (0.01 M) was examined. Tumor burden was significantly reduced and overall survival was significantly increased in animals treated with 30mg/kg MLN8237.
Product Manual Read Product Manual
Price $150
Specification5mg
Product Review 0
Vendor Information Selleck 
http://www.selleckchem.com/
2626 South Loop West, Suite 225, Houston, TX 77054 USA
TX
USA