BioProduct : Chemicals & Compounds : AZD6244
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Product Name AZD6244
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Product Description Activating mutations in the BRAF gene, primarily at V600E, are associated with poorer outcomes in patients with papillary thyroid cancer. MAPK kinase (MEK), immediately downstream of BRAF, is a promising target for ras-raf-MEK-ERK pathway inhibition. In addition to thyroid cancer, BRAF-activating mutations are prevalent in melanoma (-59%), colorectal cancer (5ĘC22%), serous ovarian cancer (-30%), and several other tumor types. Four lines bearing V600E BRAF mutations were all sensitive to AZD6244, with GI50 values ranging from 14 to 50 nM. A positive control BRAF mutant melanoma line, SKMel28, exhibited a similar GI50 of 23 nM.
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Price $160
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Vendor Information Selleck
2626 South Loop West, Suite 225, Houston, TX 77054 USA