BioProduct : Chemicals & Compounds : ABT-263
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Product Name ABT-263
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Product Description Overexpression of the prosurvival Bcl-2 family members (Bcl-2,Bcl-xL,and Mcl-1) is commonly associated with tumor maintenance, progression, and chemoresistance. Binding affinities were determined with competitive fluorescence polarization assays and a time-resolved fluorescence resonance energy transfer assay (Ki¡¯s of <1 nmol/L for Bcl-2, Bcl-xL, and Bcl-w). The oral bioavailability of ABT-263 in preclinical animal models is 20% to 50%, depending on formulation. A wide range of SCLC cellular activity was observed with ABT-263 having a 50% growth inhibition (EC50) of 110 nmol/L against the most sensitive line (H146), whereas its activity in the least sensitive line (H82) resulted in an EC50 at 22 ¦̀mol/L. In all cell lines where the EC50 was <1 ¦̀mol/L, ABT-263 was more potent than its enantiomer by a factor of>20.
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Price $250
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Vendor Information Selleck
2626 South Loop West, Suite 225, Houston, TX 77054 USA