BioProduct : Immunology : Immunohistochemistry Reagents : MSH6
Visit the product
Product Name MSH6
Product PageVisit the Product
Product Description The MutS homologue 6 protein (MSH6) is a member of the MutS homolog family required in the DNA mismatch repair system (1). MSH6 forms a MutS alpha dimer with MSH2, binding to DNA mismatches to initiate DNA repair (2). MutS alpha bends the DNA helix and recognizes single base mismatches and dinucleotide insertion-deletion loops in the DNA (2). Heterozygous mutations in the MSH6 gene are a cause of hereditary nonpolyposis colorectal cancer (HNPCC), forming a specific mispair binding complex with MSH3 (3, 4). The frequency of MSH6 mutation is higher in HNPCC than in atypical HNPCC (5). The MSH2/MSH6 dimer may also play a role in DNA homologous recombination repair (2).
Product Manual Read Product Manual
Price $250.00
Product Review 0
Vendor Information
863 Mitten Road, Suite 103
CA 94010

Phone: (877) 772-2622
Fax: (650) 583-6680