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Statistical analysis of genotype combinations? - (Apr/15/2011 )


I have one question about statistical analysis of genotype combinations in affected and control subjects.
2 genes (2 SNPs and 9 genotype combinations) and 2 groups: cancer (n=300) and control (n=300). What modern statistical analysis should I apply to identify genotype combination responsible for cancer? I usually use Chi-square and Fisher exact test. However, recently I have received commentary from journal reviewer that my statistics is very basic (((

Please, help me in this!


There's nothing wrong with the basics - they are very powerful tests. You could perhaps use an ANOVA with a posthoc test of some sort.