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TRIzol v. TRI reagent - (Mar/06/2010 )

TRI reagent from sigma versus TRIzol from invitrogen? is there a difference? could i substitute TRI reagent in this protocol:

thank you!

-prof. moriarty-

I don't see why not, but it could also depend on your downstream app. For our project, it made no difference.

-lab rat-

Hm, I assumed it's the same "chemistry"/solution just from a different supplier. I mixed TRI reagent with TriZol from our neighboring lab when I ran out of TRI reagent... for expression profiling. It worked for me.